A placebo-controlled crossover design study involving nine healthy men between the ages of 18 and 45 years was conducted to investigate the effects of caffeine, methylliberine (Dynamine™), and theacrine (TeaCrine®) on cognitive and motor performance during a first-person shooter video game.

KEY FINDING:

• Supports working memory, cognitive control, and reaction time during mentally and physically demanding tasks.*

Source: Effects of TeaCrine® (theacrine), Dynamine™ (methylliberine), and caffeine on gamer psychomotor performance in a first-person shooter video game scenario (link)

A placebo-controlled, repeated-measure, randomized crossover study involving 50 young male participants was conducted to investigate the effects of caffeine, Dynamine®, and TeaCrine® on e-gamer performance.

KEY FINDING:

• Supports improved cognitive performance without increasing self-reported anxiety or headaches.*

Source: A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers (link)

A double-blind, randomized, placebo-controlled trial involving 49 participants was used to test the effects of placebo, 300 mg caffeine, and a combination of 150 mg caffeine, 100 mg methylliberine (Dynamine ®), and 50 mg theacrine (TeaCrine®) on vigilance, marksmanship, and hemodynamic responses in tactical personnel.

KEY FINDING:

• Helps to maintain vigilance without adverse hemodynamic responses induced by caffeine alone.* 

PLA = placebo, CAF = caffeine alone, CMT = combination of 150 mg caffeine, 100 mg methylliberine, and 50 mg theacrine 

Source: Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial (link)